The research of the relationship between new single nucleotide polymorphism G5508A in the SEPT12 gene and azoospermia
نویسندگان
چکیده
The objective of the present study is to investigate the association between SEPT12 gene variation and the risk of azoospermia. In the current study, 100 infertile patients with azoospermia and 100 normal controls were analyzed for genetic alterations in the active site coding region of SEPT12, using PCRSequencing technique and mutational analysis. Genotype analysis indicated that G5508A polymorphic SEPT12 alleles were distributed in three peaks of frequency in diseases group (GG, GA and AA) and two peaks in control group (GG and GA). The frequencies of the G5508A allele and the genotype were significantly difference between the azoospermic patients and controls (p ≤ 0.05 by chi-square test). This finding suggests that G5508A variant in the SEPT12 gene may associate with the increased susceptibility
منابع مشابه
New single nucleotide polymorphism G5508A in the SEPT12 gene may be associated with idiopathic male infertility in Iranian men
BACKGROUND Male infertility is a multifactorial disorder, which affects approximately 10% of couples at childbearing age with substantial clinical and social impact. Genetic factors are associated with the susceptibility to spermatogenic impairment in humans. Recently, SEPT12 is reported as a critical gene for spermatogenesis. This gene encodes a testis specific member of Septin proteins, a fam...
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